Stem cell transplant helps immune cells in brain

A lack of immune cells to fight the bacterial and viral infections is associated with Alzheimer’s disease because B and T cells are needed to make antibodies that improve the microglia’s ability to clear away beta-amyloid plaques. Without the immune cells, there was  a two-fold increase in the beta-amyloid plaques of test mice.  Then the research team at UC Irvine led by Matthew Blurton-Jones transplanted healthy blood stem cells into the Alz. disease mice. Four months after the transplant, antibodies were present near the microglia, and there was almost a 50% reduction in the plaques.