New Alz. drug may also combat aging

An experimental drug to fight Alzheimer’s disease has an amazing effect in aging mice models.  The drug candidate, J147, produced better memory and cognition, healthier blood vessels in the brain, and other improved physiological features in the treated mice, according to the November 12, 2015 journal  Aging. Previous studies by the research team at Salk Institute had found that J147 could prevent––and even reverse––memory loss in the typical mouse subjects, mice that had the inherited form of Alzheimer’s. But inherited Alzheimer’s only accounts for about 1 percent of AD cases. The team wanted to test the drug effects on mice that age rapidly with dementia, more closely similar to age-related Alzheimer’s in humans––99 percent of the cases. Antonio Currais, lead author of the study, said, “We did not predict we’d see this sort of anti-aging effect, but J147 made old mice look like they were young, based upon a number of physiological parameters.” The team expects to begin human trials next year.