Alzheimer’s synapse damage repair

An international research team in Heidelberg has succeeded in repairing damage in the synapses between nerve cells.  Injection of a key protein, APPsa (by using viral gene shuttles), elicited repairs and clearly improved spatial memory in the brains of Alzheimer’s mouse models. Earlier studies by this group had shown that APPsa is essential in regulating the formation of synaptic functions and spatial memory. Since the synapses disappear long before the nerve cells die, this study offers hope that the nerve cells will be protected.  “While dead nerve cells are irretrievably lost, damaged synapses can be regenerated in the elderly,” the lead neurobiologist, Dr. Ulrike Müller emphasized.